Roots Analysis has announced the addition of “Targeted Protein Degradation Market” report to its list of offerings.
Small-molecule-induced protein degradation has been demonstrated to possess the potential to drug a broader range of proteinaceous biological targets. It involves the selective recruitment of the body’s inherent protein degradation pathways, to eliminate disease causing / associated proteins, using bifunctional small molecule drugs. Presently, the most popular and promising class of interventions in this field of research, is proteolysis targeting chimeras (PROTACs); these can simultaneously bind a target protein and an E3-ubiquitin ligase, and thereby, facilitate the selective ubiquitination and eventual proteasome-mediated degradation of the target protein. The most interesting feature of this mechanism of drug action is the fact that PROTACs and other targeted protein degraders can eliminate protein targets regardless of their function.
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Key Market Insights
Presently, more than 150 targeted protein degradation-based therapeutics are currently under development
Around 75% of the aforementioned candidates are in the preclinical and discovery stages, followed by those that are being evaluated in clinical trials (25%). The these degrader molecules are PROTAC (26), followed by DUB inhibitors (15%), protein homeostatic modulators (14%) and SERDs/SARDs (13%).
Over 40 targeted protein degradation enabling technologies are presently available / under development
Of these, the PROTAC® platform is presently considered the most popular, with 15 product candidates, developed using the same technology, under investigation. On the other hand, there are presently 10 technologies that are designed to design / develop DUB inhibitors.
Around 80 targeted protein degradation companies claim to be engaged in the development of targeted protein degradation-based therapeutics
Post 2010, there has been a notable surge in the number of companies developing targeted protein degraders. Majority of the firms engaged in this field (57%) are based in North America, followed by Europe (27%) and the Asia Pacific (16%).
Over 80 registered clinical trials are presently assessing targeted protein degradation-based therapeutics, worldwide
It is worth mentioning that most of the clinical research in this direction is being conducted in Europe (60%), followed by North America and the Asia Pacific. However, more than 40% of the total number of patients enrolled in such trials are in North America.
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Key Questions Answered
- Who are the leading industry and non-industry players in this market?
- What are the key therapeutic areas for which targeted protein degraders are being / have been developed?
- Which geographies are more active in conducting clinical trials on targeted protein degraders?
- What kind of partnership models are commonly adopted by industry stakeholders?
- Which are the leading administering institute centers supporting research in this domain?
- What is the trend of capital investments in the targeted protein degradation market?
- How has the intellectual property landscape in this market evolved over the years?
- How is the current and future market opportunity likely to be distributed across key market segments?
The research includes detailed profiles of key players (listed below); each profile features an overview of the company, its financial information (if available), brief descriptions of its proprietary drug(s) and an informed future outlook.
- Arvinas
- AstraZeneca
- BioTheryX
- C4 Therapeutics
- Captor Therapeutics
- Celgene
- Genentech
- Hinova Pharmaceuticals
- Kangpu Biopharmaceuticals
- Kymera Therapeutics
- Mission Therapeutics
- Progenra
- Radius Health
- Sanofi Genzyme
- Zenopharm
For additional details, please visit
https://www.rootsanalysis.com/reports/view_document/protein-degradation-market/289.html
or email sales@rootsanalysis.com
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Contact:
Ben Johnson
+1 (415) 800 3415
+44 (122) 391 1091
Ben.johnson@rootsanalysis.com
