D-dimer is a fibrin degradation product that is often tested to measure any clot formation. The covid profile test analyses the levels of D-dimer in the blood. Amid the covid pandemic, it was found out that elevated d-dimer levels have been known to be associated with the severity of the diseases.
How is D-dimer generated?
The liver produces fibrinogen and it is one of the most important proteins involved in the coagulation process. A single fibrinogen molecule is an asymmetrical dimer that consists of three pairs of three different polypeptide chains. Each of these intertwined polypeptide chains consists of a single fibrin molecule gelled together by disulfide bonds.
If any injury occurs, the body’s immune system releases a plasminogen activator to enable molecule binding of the fiber on the surface of plasmin. This fibrin brown plasmin disintegrates the vibrant network into several soluble fragments, out of which be dimer is one of the byproducts.
What is the D-dimer measured?
Suppose there is a D-Dimer present in the blood plasma. In that case, it is often used as a clinical biomarker to identify the thrombotic activity and also to diagnose conditions like pulmonary embolism (PE), deep vein thrombosis (DVT), venous thromboembolism (VTE), and disseminated intravascular coagulation (DIC).
D-dimer has a half-life of roughly eight hours until the kidney clears it all out. Covid profile test in Delhi analyses the D-dimer levels in the blood to find out if any thrombotic activity is present in the immune system.
If the D- dimer levels are present inside the body, then it indicates active cancer, immobilization or recent surgery. Other than these conditions, D- dimer level can also rise due to advanced age, chronic inflammatory diseases, and pregnancy.
Importance of identifying COVID-19 biomarkers
It has been estimated that about 10 to 15% of Covid- 19 patients experience a critical form of this disease. Covid-19 can cause severe pneumonia, respiratory failure, hypoxia, all of which will require supportive care and supplemental nasal oxygen.
If at the onset of the Covid- 19 diseases, a patient does a Covid profile test, then the doctor can easily identify the elevated D-dimer levels to detect the severity of the disease.
About 5 percent of severe Covid 19 cases have been found to decline and cause further acute respiratory distress syndrome or multiple organ failure. Both of these medical conditions require intensive care units and hospitalization with mechanical ventilation or extracorporeal membrane oxygenation (ECMO).
Though the Covid-19 has spread far and frequently, there has been a limited understanding of why certain individuals develop ARDS and MOF and others do not.
Covid profile test in Delhi is a reliable biomarker test to identify the elevated d dimer levels, which helps the doctor detect the severity of the disease early.
D-dimer and COVID-19
Several studies have been conducted to measure the d dimer levels in hospitalized Covid-19 patients. The studies have proved that D- dimer level is an important biomarker that would be useful in predicting patient outcomes. In a study conducted in China, it was reported that patients having D- dimer levels at a median of 4.6 µg/mL did not survive. In contrast, patients having an average D-Dimer level at 0.6 µg/mL survived.
All these data indicate that D-dimer testing and other biomarkers in the covert profile test can assist during the treatment of COVID-19 patients. Having a covid profile test in Delhi can help you validate the D- Dimer test’s role in the decision-making process.
