The Chromosomal Microarray Test is a powerful new diagnostic method that uses a small piece of DNA instead of a full chromosome to identify small genetic changes. This type of analysis is better at detecting rare and potentially life-threatening variants than conventional chromosome analysis. This technique can detect a variety of health-related problems and is recommended by the ACOG committee.
The Chromosomal Microarray Test (CMA) is a first-tier genetic test. It is becoming the standard for suspected chromosomal and developmental disorders. CMA also helps in identifying multiple congenital anomalies and other syndromes. It is important for the detection of copy-neutral loss of heterozygosity or CNV. The CMA test can also be used for cancer screening and for prenatal diagnosis.
The CMA procedure has a few advantages. The microarray consists of thousands of probes located in known locations on the chromosomes. The CMA detects imbalances in chromosomal material. It compares DNA from a patient with a control sample. The difference in copy number also called gains, losses, duplications, or deletions is then used to determine a patient’s health condition.
A chromosomal microarray can detect structural abnormalities in fetuses. In one study, 100 subjects with fetal abnormalities were recruited. The results revealed that 12% of women had a high percentage of pCNVs. The results of the CMA were also statistically significant. In many cases, the resulting reports led to the termination of the pregnancy.
Chromosomal Microarray tests in Delhi NCR India are performed by physicians to detect structural abnormalities. They are also used to diagnose fetal structural disorders. In a single study, 100 subjects were enrolled in the test. The average prevalence of chromosomal abnormalities was 13%. The occurrence rate was 18% for thoracic anomalies, 19% for renal anomalies, and 12% for chromosomal disorders.
The Chromosomal Microarray is a comprehensive genetic test. It identifies a wide variety of small mutations in the genome. It can identify large deletions and copy number variations in the individual. It is recommended for people with signs of intellectual disability or developmental delays. However, the Chromosomal Microarray does not identify fragile X syndrome, so a separate DNA test for this disorder is needed.
The microarray is a highly accurate test to find small genetic changes. It can detect large deletions and sub-microscopic rearrangements, among other defects. The results are also useful for screening children for autism. A chromosomal microarray is a very sensitive test and should be conducted if a child has a history of any of these conditions.
